Cenoderm

– Origin: Allograft Dermis (Acellular Dermal Matrix).
– Dual-Layer Function:
– Smooth side (Collagen I & V) for cell occlusion.
– Porous side (Collagen II & IV) for revascularization.
– Versatility: Available in Thin, Medium, and Thick options to suit submerged or exposed techniques.
– Long-Lasting: Longer resorption profile compared to standard membranes (up to 6+ months for thick versions).
– Clinical Use: Ideal for GBR, GTR, Flap Extension, and soft tissue augmentation without the need for a second surgical site (donor site).

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Product Description

Cenoderm is an allograft derived from human skin (dermis), designed as an effective alternative to autogenous connective tissue grafts. It serves as a biological barrier in GTR (Guided Tissue Regeneration) procedures. Compared to standard membranes, Cenoderm exhibits a longer resorption time and, in thicker variations, allows for open healing (exposure).

Structural Mechanism & Orientation: Cenoderm features a dual-surface structure, each with distinct collagen compositions:

  • Smooth Surface: Contains Type I and V collagen. This side should face outward (towards the soft tissue/oral cavity) to enhance cell guidance and barrier function.

  • Porous Surface: Contains Type II and IV collagen. This side must be placed facing the bone graft or powder to promote revascularization and blood supply.

Thickness Classifications & Resorption: Cenoderm is available in three categories based on thickness and exposure capability:

  1. Thin (0.2 – 0.6 mm): Non-exposable. Max resorption time: 2 months.

  2. Medium (0.6 – 0.9 mm): Up to 10-15% exposure allowed. Max resorption time: 4 months.

  3. Thick (> 1.0 mm): Suitable for exposed placement (e.g., FGG substitute). Resorption time: > 6 months.

Surgical Notes:

  • Fixation: When used in an exposed manner, the matrix must be securely fixed with sutures.

  • Vascularization: It is mandatory to tuck the membrane at least 2 mm under the gingival flap on all sides to ensure adequate blood supply.

Indications:

  • Treatment of periodontal and gingival diseases.

  • Implant dentistry and maxillofacial surgery.

  • Sinus lift procedures (protection of the Schneiderian membrane).

  • Socket preservation (post-extraction).

  • Alveolar ridge preservation and reconstruction.

  • Vertical and horizontal bone augmentation.

  • Treatment of 1 to 3-wall intrabony defects.

  • Substitute for Free Gingival Grafts (FGG) and GTR.

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